Table 1 Overview of the detected genetic alterations in the spermatocytic tumor and the spindle cell tumor using aCGH/SNP, NGS (Oncomine Precision Assay) and immunohistochemical profile
| Â | Spermatocytic tumor | Spindle cell tumor |
|---|---|---|
Chromosomal losses (aCGH/SNP) | Monosomy 15 (70%) | Monosomy 22 (40%) |
Chromosomal gains (aCGH/SNP) | Trisomies 5, 9, 18, 20, 22 (70%) | 4q (whole arm, 20%) Trisomy 7 (40%) |
cnLOH (aCGH/SNP) | 11p (43.5 Mb, 100%) 16p (35.2 Mb, 100%) | None |
Sequence variations (NGS) | HRAS gene (p.G61R, Exon 3, 90%) | None |
SALL4 stain (Immunohistochemistry) | Positive (diffuse) | Negative |