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Table 2 Outcome definition in each included study

From: Effectiveness of methenamine hippurate in preventing urinary tract infections: an updated systematic review, meta-analysis and trial sequential analysis of randomized controlled trials

Study

Outcome definition

Category

Botros, 2022 [13]

Recurrent UTI defined as two culture-proven UTIs within 6 months, or three within 1 year with associated symptoms.

Symptomatic UTI + Positive Culture

Brumfitt, 1983 [14]

At least one episode documented bacteriologically, symptomatic recurrence monitored over 12 months.

Symptomatic UTI + Positive Culture

Chu, 2016 [15]

Symptomatic UTI post-procedure defined by clinical symptoms and urinary analysis, no consistent culture data.

Symptomatic UTI + Unknown Culture

Gundersen, 1986 [17]

Frequent cystitis defined as two or more symptomatic episodes in the previous 6 months, evaluated in elderly women.

Symptomatic UTI + Positive Culture

Harding, 2022 [16]

Incidence of symptomatic antibiotic-treated UTIs, clinical diagnosis preferred over microbiological confirmation.

Symptomatic UTI (Clinical)

  1. Symptomatic UTI + Positive Culture At least one episode documented bacteriologically, symptomatic recurrence monitored over 12 months
  2. Symptomatic UTI + Unknown Culture Symptomatic UTI post-procedure defined by clinical symptoms and urinary analysis, no consistent culture data
  3. Symptomatic UTI (Clinical) Incidence of symptomatic antibiotic-treated UTIs, clinical diagnosis preferred over microbiological confirmation